SCHEMBL7475063

SCHEMBL7475063

O=C1NC(=O)C(Br)(Cc2ccccc2)C(=O)N1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MMP9 P14780 10/20 0.50
MMP2 P08253 9/20 0.50
MMP13 P45452 7/20 0.50
MMP8 P22894 6/20 0.50
CYP3A4 P08684 2/20 0.42
ADAM17 P78536 2/20 0.41
ALDH1A1 P00352 2/20 0.40
MAPT P10636 2/20 0.40
CYP2C9 P11712 2/20 0.40
KDM4E B2RXH2 1/20 0.40
CYP1A2 P05177 1/20 0.40
HPGD P15428 1/20 0.40
CYP2C19 P33261 1/20 0.40
CACNA1B Q00975 1/20 0.40
APBA1 Q02410 1/20 0.40
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
MMP3 P08254 2/20 0.39
CACNA1F O60840 1/20 0.38
HTR2A P28223 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5448618 0.81 MMP9 (0.64) MMP9MMP2MMP13MMP8CYP3A4
SCHEMBL28010729 0.78 ATM (0.48) CYP3A4ALDH1A1MAPTCYP2C9KDM4E
SCHEMBL16865428 0.76 MMP9 (0.56) MMP9MMP2MMP13MMP8CYP3A4
SCHEMBL11276893 0.76 MMP9 (0.50) MMP9MMP2MMP13MMP8CYP3A4
SCHEMBL16865403 0.76 MMP9 (0.50) MMP9MMP2MMP13MMP8CYP3A4
SCHEMBL6267425 0.74 MMP13 (0.55) MMP9MMP2MMP13MMP8CYP3A4
SCHEMBL5836631 0.74 ALDH1A1 (0.61) MMP9MMP2MMP13MMP8ALDH1A1
SCHEMBL28010727 0.74 KDM4E (0.47) MMP9MMP2MMP13MMP8CYP3A4
SCHEMBL28010057 0.72 TP53 (0.48) CYP3A4ALDH1A1MAPTCYP2C9KDM4E
SCHEMBL4174555 0.72 CYP3A4 (0.49) MMP9MMP2MMP13MMP8CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1318406-C New barbituric acid derivatives, processes for their prodn. and pharmaceutical agent contg. same BOEHRINGER MANNHEIM GMBH (DE) 2007-05-30 CN disclosed
US-6472396-B1 Barbituric acid derivatives, processes for their production and pharmaceutical agents containing these compounds ROCHE DIAGNOSTICS GMBH (DE) 2002-10-29 US disclosed
EP-0869947-B1 BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS ROCHE DIAGNOSTICS GMBH (DE) 2002-10-23 EP disclosed
US-6110924-A MATRIX METALLOPROTEASE INHIBITORS ROCHE DIAGNOSTICS GMBH (DE) 2000-08-29 US disclosed
CN-1209123-A New barbituric acid derivatives, processes for their prodn. and pharmaceutical agent contg. same BOEHRINGER MANNHEIM GMBH (DE) 1999-02-24 CN disclosed
EP-0869947-A1 NEW BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS Roche Diagnostics GmbH (DE) 1998-10-14 EP disclosed
WO-1997023465-A1 NEW BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS BOEHRINGER MANNHEIM GMBH (DE) 1997-07-03 WO disclosed