SCHEMBL7337247

SCHEMBL7337247

C[Si](C)(C)CCOC(=O)CCCN[C]=O

nearest known ligand 0.37

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
DGKA P23743 1/20 0.37
EPHX2 P34913 13/20 0.35
TOP2A P11388 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28897216 0.94 DGKA (0.33) DGKAEPHX2TOP2A
SCHEMBL28433398 0.88 DGKA (0.39) DGKAEPHX2
SCHEMBL28438959 0.85 DGKA (0.33) DGKAEPHX2TOP2A
SCHEMBL16862571 0.81 ACHE (0.47)
SCHEMBL5651628 0.78 CYP1A2 (0.52) EPHX2TOP2A
SCHEMBL1401029 0.77 ADH1B (0.37) DGKAEPHX2TOP2A
SCHEMBL23462146 0.75 DGKA (0.44) DGKAEPHX2
SCHEMBL9061933 0.75 DGKA (0.44) DGKAEPHX2
SCHEMBL6535251 0.75 DGKA (0.59) DGKA
SCHEMBL9099953 0.75 DGKA (0.55) DGKAEPHX2TOP2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113226331-A Medicine for improving infertility or pregnancy state 山口晃史 2021-08-06 CN disclosed
CN-112533599-A Therapeutic agent for humoral immunity-related diseases in maternal-fetal relationship 山口晃史 2021-03-19 CN disclosed
EP-0581959-B1 USE OF MACROLIDE COMPOUNDS FOR EYE DISEASES FUJISAWA PHARMACEUTICAL CO (JP) 2001-01-17 EP disclosed
US-5770607-A EYE DROPS CONTAINING TRICYCLO COMPOUND FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1998-06-23 US disclosed
US-5643901-A TREATMENT OF UROGENITAL DISORDERS, NERVOUS SYSTEM DISORDERS, ANTIDIABETIC AGENTS OR CARDIOVASCULAR DISORDERS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-07-01 US disclosed
EP-0428169-B1 Aqueous liquid formulations FUJISAWA PHARMACEUTICAL CO (JP) 1995-03-01 EP disclosed
EP-0581959-A1 USE OF MACROLIDE COMPOUNDS FOR EYE DISEASES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-02-09 EP disclosed
EP-0533930-A1 USE OF A MACROLIDE COMPOUND SUCH AS FK 506 FOR MANUFACTURING A MEDICAMENT FOR TREATING IDIOPATHIC THROMBOCYTOPENIC PURPURA AND BASEDOW'S DISEASE FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1993-03-31 EP disclosed
EP-0428169-A2 Aqueous liquid formulations FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1991-05-22 EP disclosed
EP-0406791-A2 Aqueous liquid composition for external use FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1991-01-09 EP disclosed