Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.36 |
| ▸ | TET3 | O43151 | 1/20 | 0.36 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.36 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8356143 | 0.98 | AKR1C1 (0.46) | AKR1C1OPRM1LMNANPSR1HDAC1 | |
| SCHEMBL700243 | 0.87 | AKR1C1 (0.55) | AKR1C1LMNANPSR1HSD11B1CYP2D6 | |
| Hydrochloric Acid SCHEMBL23779012 | 0.85 | AKR1C1 (0.53) | AKR1C1LMNANPSR1HSD11B1CYP2D6 | |
| SCHEMBL8636689 | 0.84 | OPRM1 (0.41) | OPRM1LMNANPSR1HDAC1HSD11B1 | |
| SCHEMBL373567 | 0.83 | AKR1C1 (0.68) | AKR1C1OPRM1HDAC1HSD11B1TACR1 | |
| SCHEMBL4827944 | 0.83 | AKR1C1 (0.68) | AKR1C1LMNANPSR1HSD11B1KMT2A | |
| Hydrochloric Acid SCHEMBL8355478 | 0.83 | OPRM1 (0.40) | OPRM1LMNANPSR1HDAC1HSD11B1 | |
| Ammonia Solution, Strong SCHEMBL3210975 | 0.81 | AKR1C1 (0.66) | AKR1C1OPRM1HDAC1HSD11B1TACR1 | |
| Hydrochloric Acid SCHEMBL18281540 | 0.81 | AKR1C1 (0.66) | AKR1C1OPRM1HDAC1HSD11B1TACR1 | |
| SCHEMBL29514621 | 0.81 | AKR1C1 (0.66) | AKR1C1LMNANPSR1HSD11B1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0844877-A1 | USE OF OXIDO-SQUALENE CYCLASE INHIBITORS TO LOWER BLOOD CHOLESTEROL | ZENECA LIMITED (GB) | 1998-06-03 | — | — | EP | disclosed |
| WO-1997006802-A1 | USE OF OXIDO-SQUALENE CYCLASE INHIBITORS TO LOWER BLOOD CHOLESTEROL | ZENECA LIMITED (GB) | 1997-02-27 | — | — | WO | disclosed |