⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL419742 | 0.76 | — | — | |
| SCHEMBL420617 | 0.76 | — | — | |
| SCHEMBL979771 | 0.76 | — | — | |
| SCHEMBL18845026 | 0.73 | — | — | |
| SCHEMBL9423576 | 0.71 | — | — | |
| SCHEMBL981029 | 0.70 | CALM1 (0.42) | — | |
| SCHEMBL7303886 | 0.70 | CA1 (0.35) | — | |
| SCHEMBL7343489 | 0.69 | CA1 (0.38) | — | |
| SCHEMBL7303716 | 0.67 | HIF1A (0.43) | — | |
| SCHEMBL9422903 | 0.67 | HIF1A (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120158115-A | Surface modified pre-dispersed pigment and modification method | 安徽和盛新材料科技有限公司 | 2025-06-17 | — | — | CN | claimed |
| CN-120208954-B | 4- { [3- (1H-pyrrolo [2,3-b ] pyridine-1-methyl) phenyl ] amino } furan-2 (5H) -one compound, preparation and application thereof | 沈阳药科大学 | 2026-05-19 | — | — | CN | disclosed |
| CN-120158115-A | Surface modified pre-dispersed pigment and modification method | 安徽和盛新材料科技有限公司 | 2025-06-17 | — | — | CN | disclosed |
| CN-109970743-B | 5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds as JAK inhibitors | 豪夫迈·罗氏有限公司 | 2022-03-04 | — | — | CN | disclosed |
| EP-3286198-B1 | COMPOUNDS FOR TREATING PRURITIC CONDITIONS | TREVI THERAPEUTICS INC (US) | 2021-02-24 | — | — | EP | disclosed |
| EP-3145929-B1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS WHICH ARE JAK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-01-13 | — | — | EP | disclosed |
| US-20190322661-A1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS,COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2019-10-24 | — | — | US | disclosed |
| US-20180305355-A1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS,COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2018-10-25 | — | — | US | disclosed |
| EP-3286198-A1 | COMPOUNDS FOR TREATING PRURITIC CONDITIONS | Trevi Therapeutics, Inc. (US) | 2018-02-28 | — | — | EP | disclosed |
| US-20170145020-A1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS,COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2017-05-25 | — | — | US | disclosed |
| US-9604984-B2 | 5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds, compositions and methods of use thereof | GENENTECH, INC. (US) | 2017-03-28 | — | — | US | disclosed |
| WO-2016172613-A1 | COMPOUNDS FOR TREATING PRURITIC CONDITIONS | Trevi Therapeutics, Inc. (US) | 2016-10-27 | — | — | WO | disclosed |
| US-20160311832-A1 | COMPOUNDS FOR TREATING PRURITIC CONDITIONS | Trevi Therapeutics, Inc. | 2016-10-27 | — | — | US | disclosed |
| US-20160237086-A1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS,COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2016-08-18 | — | — | US | disclosed |
| US-9346815-B2 | 5-chloro-2-difluoromethoxyphenyl pyrazolopyrimidine compounds, compositions and methods of use thereof | GENENTECH, INC. (US) | 2016-05-24 | — | — | US | disclosed |
| US-20150336962-A1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2015-11-26 | — | — | US | disclosed |
| WO-2015177326-A1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS WHICH ARE JAK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-11-26 | — | — | WO | disclosed |
| EP-0578080-B1 | 3,9-disubstituted-spiro (5.5)undecanes active on the cardiovascular system, process for their preparation and pharmaceutical composition containing same | SIGMA TAU IND FARMACEUTI (IT) | 1997-04-23 | — | — | EP | disclosed |
| US-5444082-A | Treats hypertension and heart failure | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1995-08-22 | — | — | US | disclosed |
| EP-0578080-A2 | 3,9-disubstituted-spiro (5.5)undecanes active on the cardiovascular system, process for their preparation and pharmaceutical composition containing same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1994-01-12 | — | — | EP | disclosed |