Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | NPY1R | P25929 | 1/20 | 0.61 |
| ▸ | NPY2R | P49146 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7326890 | 0.88 | MAPT (0.55) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL7333826 | 0.85 | TP53 (0.47) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL7333903 | 0.85 | LMNA (0.60) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL7306239 | 0.83 | LMNA (0.78) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL7328478 | 0.82 | LMNA (0.72) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL8116038 | 0.81 | LMNA (0.76) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL6795295 | 0.81 | MAPT (0.75) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL7297671 | 0.80 | PDE3B (0.53) | LMNANPY1RNPY2RMAPTKMT2A | |
| SCHEMBL7335052 | 0.80 | HRH3 (0.57) | MAPTHRH3SMN1; SMN2PDE3BKCNH2 | |
| SCHEMBL7338143 | 0.77 | MAPT (0.50) | LMNANPY1RNPY2RMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5204463-A | Substituted methoxyphenyl-4,5 dihydro-3(2H)-pridazinones having cardiotonic and beta blocking activities | GLAXO INC. (US) | 1993-04-20 | — | — | US | disclosed |
| US-5096904-A | Congestive heart failure | GLAXO INC. (US) | 1992-03-17 | — | — | US | disclosed |
| US-5053338-A | Hydrolysis of ester to obtain an optically enriched mixture of a phenol enantiomer | GLAXO INC. (US) | 1991-10-01 | — | — | US | disclosed |
| EP-0412814-A2 | Pyridazinones having cardiotonic and beta blocking activity | GLAXO WELLCOME INC. (US) | 1991-02-13 | — | — | EP | disclosed |