Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | EDNRB | P24530 | 1/20 | 0.35 |
| ▸ | EDNRA | P25101 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8790361 | 0.83 | MAPT (0.37) | SMN1; SMN2LMNAMAPK1MAPTUSP2 | |
| SCHEMBL7338352 | 0.77 | EDNRA (0.45) | SMN1; SMN2LMNAMAPK1ALDH1A1MAPT | |
| SCHEMBL23515193 | 0.75 | EDNRB (0.47) | SMN1; SMN2LMNAMAPK1ALDH1A1MAPT | |
| SCHEMBL7333299 | 0.72 | EDNRA (0.51) | MAPTUSP2EDNRBEDNRAKMT2A | |
| SCHEMBL20534751 | 0.67 | ALDH1A1 (0.42) | SMN1; SMN2MAPK1ALDH1A1MAPTCRHBP | |
| SCHEMBL5794655 | 0.66 | ALDH1A1 (0.46) | SMN1; SMN2LMNAMAPK1ALDH1A1MAPT | |
| SCHEMBL10441731 | 0.65 | ALDH1A1 (0.51) | SMN1; SMN2MAPK1ALDH1A1MAPTMEN1 | |
| SCHEMBL29043606 | 0.64 | ALDH1A1 (0.47) | MAPK1ALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL140150 | 0.64 | MAPT (0.51) | SMN1; SMN2ALDH1A1MAPTUSP2HTT | |
| SCHEMBL30300332 | 0.64 | MAPT (0.51) | SMN1; SMN2ALDH1A1MAPTUSP2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5668176-A | ENDOTHELIN ANTAGONIST | MERCK & CO. INC. (US) | 1997-09-16 | — | — | US | disclosed |
| US-5565485-A | TREATING CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1996-10-15 | — | — | US | disclosed |
| WO-1996009818-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS FOR THE TREATMENT OF EMESIS | MERCK & CO., INC. (US) | 1996-04-04 | — | — | WO | disclosed |
| WO-1996004905-A1 | PHENOXYPHENYLACETIC ACID DERIVATIVES | MERCK & CO., INC. (US) | 1996-02-22 | — | — | WO | disclosed |