Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Nafamostat. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 known ✓ | P00742 | 2/20 | 0.54 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.58 |
| ▸ | PRSS1 | P07477 | 9/20 | 0.54 |
| ▸ | F2 | P00734 | 5/20 | 0.54 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.54 |
| ▸ | C1R | P00736 | 2/20 | 0.54 |
| ▸ | KLK1 | P06870 | 2/20 | 0.54 |
| ▸ | PLG | P00747 | 4/20 | 0.50 |
| ▸ | HPN | P05981 | 4/20 | 0.50 |
| ▸ | F12 | P00748 | 3/20 | 0.50 |
| ▸ | HGFAC | Q04756 | 2/20 | 0.50 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.50 |
| ▸ | MLNR | O43193 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.50 |
| ▸ | C1S | P09871 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nafamostat SCHEMBL1568755 | 0.90 | FTO (0.70) | FTOPRSS1F2KLKB1C1R | |
| Nafamostat SCHEMBL29832433 | 0.90 | FTO (0.70) | FTOPRSS1F2KLKB1C1R | |
| Nafamostat SCHEMBL564665 | 0.90 | FTO (0.70) | FTOPRSS1F2KLKB1C1R | |
| Nafamostat SCHEMBL874941 | 0.87 | FTO (0.64) | FTOPRSS1F2KLKB1C1R | |
| Nafamostat SCHEMBL135503 | 0.86 | PRSS1 (0.64) | FTOPRSS1F2KLKB1C1R | |
| Nafamostat SCHEMBL29429443 | 0.86 | PRSS1 (0.64) | FTOPRSS1F2KLKB1C1R | |
| Nafamostat SCHEMBL29429445 | 0.86 | PRSS1 (0.64) | FTOPRSS1F2KLKB1C1R | |
| Nafamostat SCHEMBL16069975 | 0.86 | PRSS1 (0.64) | FTOPRSS1F2KLKB1C1R | |
| Nafamostat SCHEMBL3302794 | 0.85 | PRSS1 (0.63) | FTOPRSS1F2KLKB1C1R | |
| Nafamostat SCHEMBL7345508 | 0.84 | PRSS1 (0.62) | FTOPRSS1F2KLKB1C1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0048433-B1 | NOVEL AMIDINE COMPOUNDS, PROCESS FOR PRODUCING SAME AND ANTI-COMPLEMENT AGENT COMPRISING THEM | TORII & CO., LTD. (JP) | 1986-05-28 | — | — | EP | disclosed |
| US-4532255-A | Amidine compounds and anticomplement agent comprising same | TORII & CO., LTD. (JP) | 1985-07-30 | — | — | US | disclosed |
| US-4454338-A | 6-AMIDINO-2-NATHTHYL-4-GUANIDINOBENZOATE | TORII & CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |