Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NT5E | P21589 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7328515 | 1.00 | TDP1 (0.50) | TDP1ATMHTR2ARAB9ANPC1 | |
| SCHEMBL14275292 | 0.84 | GAA (0.54) | RAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14275297 | 0.84 | GAA (0.54) | RAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6978503 | 0.82 | BCL9 (0.52) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL7761879 | 0.82 | GAA (0.49) | TDP1RAB9ANPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1714950 | 0.80 | HTR2A (0.70) | TDP1HTR2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL27818621 | 0.77 | MGLL (0.52) | TDP1HTR2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL1803004 | 0.76 | ATM (0.55) | ATMHTR2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL17726690 | 0.76 | GAA (0.58) | HTR2ARAB9ANPC1ALDH1A1CYP2C9 | |
| SCHEMBL2386516 | 0.75 | FABP7 (0.54) | TDP1RAB9ANPC1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555479-B1 | EPOXYSUCCINAMIC ACID DERIVATIVE | TAISHO PHARMACEUTICAL CO LTD (JP) | 1996-12-18 | — | — | EP | disclosed |
| EP-0407017-B1 | Epoxysuccinic acid derivatives useful as specific inhibitors of cathepsin B | TAISHO PHARMACEUTICAL CO LTD (JP) | 1995-05-17 | — | — | EP | disclosed |
| US-5281717-A | Pharmaceuticals | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1994-01-25 | — | — | US | disclosed |
| US-5068354-A | Cathepsin B inhibitors, enzyme inhibitors for muscular disorders | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 1991-11-26 | — | — | US | disclosed |
| EP-0407017-A1 | Epoxysuccinic acid derivatives useful as specific inhibitors of cathepsin B | TAISHO PHARMACEUTICAL CO. LTD (JP) | 1991-01-09 | — | — | EP | disclosed |