Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 5/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.36 |
| ▸ | CDC7 | O00311 | 3/20 | 0.36 |
| ▸ | DAO | P14920 | 2/20 | 0.34 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.32 |
| ▸ | CDK8 | P49336 | 2/20 | 0.32 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.32 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7346574 | 0.93 | KDM4E (0.39) | CYP11B2CYP11B1CYP19A1CDC7DAO | |
| SCHEMBL7341653 | 0.82 | PKN2 (0.32) | CYP11B2CYP11B1CYP19A1CDC7DAO | |
| SCHEMBL7342355 | 0.81 | CES1 (0.40) | KDM4EALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL7338490 | 0.81 | AURKB (0.44) | CDC7DAOPKN2KDM4EALDH1A1 | |
| SCHEMBL7347683 | 0.81 | KDM4E (0.43) | CYP11B2CDC7PKN2KDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL7337010 | 0.80 | CES1 (0.39) | KDM4EALDH1A1HPGDHSD17B10TDP1 | |
| SCHEMBL11074795 | 0.79 | CDC7 (0.34) | CYP11B2CYP11B1CDC7PKN2 | |
| SCHEMBL7346248 | 0.78 | SIRT3 (0.41) | CYP11B2CDC7DAOKDM4EROCK2 | |
| SCHEMBL7347592 | 0.77 | MAPK14 (0.39) | — | |
| SCHEMBL7346402 | 0.75 | KDM4E (0.48) | CYP11B2CDC7KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511569-A | Tricyclic lactams and derivatives useful in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-04-16 | — | — | US | disclosed |
| EP-0102046-A1 | Tricyclic lactams, method for making them, pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-03-07 | — | — | EP | disclosed |