Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 3/20 | 0.44 |
| ▸ | INCENP | Q9NQS7 | 3/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.44 |
| ▸ | CDC7 | O00311 | 3/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | TTK | P33981 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7340801 | 0.92 | AURKB (0.43) | AURKBINCENPPDE3BPDE3ACDC7 | |
| SCHEMBL7337644 | 0.87 | AURKB (0.46) | AURKBINCENPPDE3BPDE3ACDC7 | |
| SCHEMBL7338656 | 0.81 | CYP11B2 (0.36) | CDC7KDM4EALDH1A1CYP1A2HPGD | |
| SCHEMBL7346402 | 0.80 | KDM4E (0.48) | PDE3BPDE3ACDC7PDE4APDE4B | |
| SCHEMBL7402936 | 0.80 | CDC7 (0.36) | CDC7KDM4EMAPTCYP3A4CASP1 | |
| SCHEMBL7338264 | 0.79 | TYMS (0.46) | AURKBINCENPPDE3BPDE3APDE4A | |
| SCHEMBL7403980 | 0.77 | KDM4C (0.39) | CDC7MEN1KMT2ACASP1ROCK2 | |
| SCHEMBL7403456 | 0.76 | AAK1 (0.46) | CDC7ROCK2 | |
| SCHEMBL7347975 | 0.75 | TYMS (0.51) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL7337834 | 0.75 | PKN2 (0.41) | CDC7KDM4EALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511569-A | Tricyclic lactams and derivatives useful in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-04-16 | — | — | US | disclosed |
| EP-0102046-A1 | Tricyclic lactams, method for making them, pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-03-07 | — | — | EP | disclosed |