Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 7/20 | 0.39 |
| ▸ | CCNC | P24863 | 7/20 | 0.36 |
| ▸ | CDK8 | P49336 | 7/20 | 0.36 |
| ▸ | HASPIN | Q8TF76 | 4/20 | 0.36 |
| ▸ | CDK19 | Q9BWU1 | 4/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7347683 | 0.87 | KDM4E (0.43) | SIRT3TDP1CDC7CCNCCDK8 | |
| SCHEMBL7340109 | 0.81 | BCAT2 (0.40) | KDM4E | |
| SCHEMBL7337644 | 0.81 | AURKB (0.46) | CDC7CCNCCDK8KDM4EHTT | |
| SCHEMBL7338656 | 0.78 | CYP11B2 (0.36) | SIRT3TDP1CDC7CCNCCDK8 | |
| SCHEMBL7341653 | 0.78 | PKN2 (0.32) | CDC7CYP11B2DAO | |
| SCHEMBL7346574 | 0.76 | KDM4E (0.39) | CDC7CYP11B2KDM4EROCK2DAO | |
| SCHEMBL7346618 | 0.75 | AURKA (0.36) | TDP1KDM4E | |
| SCHEMBL7339359 | 0.75 | KDM4E (0.49) | CYP11B2KDM4E | |
| SCHEMBL7348959 | 0.74 | CSNK1A1 (0.39) | CYP11B2KDM4E | |
| SCHEMBL7339006 | 0.72 | NOTUM (0.44) | KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511569-A | Tricyclic lactams and derivatives useful in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-04-16 | — | — | US | disclosed |
| EP-0102046-A1 | Tricyclic lactams, method for making them, pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-03-07 | — | — | EP | disclosed |