Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | REN | P00797 | 4/20 | 0.32 |
| ▸ | CAPN1 | P07384 | 5/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7330557 | 0.88 | AVPR1A (0.38) | TSHRAGTR2RENCAPN1ROCK2 | |
| SCHEMBL7329409 | 0.88 | REN (0.42) | MEN1ALDH1A1KMT2ARENSMN1; SMN2 | |
| SCHEMBL7338889 | 0.88 | KMT2A (0.39) | TSHRCA12CA9AGTR2CA1 | |
| SCHEMBL7338775 | 0.87 | CAPN1 (0.34) | TSHRCA12CA9CA1MEN1 | |
| SCHEMBL7330563 | 0.85 | AVPR1A (0.36) | TSHRAGTR2MEN1ALDH1A1KMT2A | |
| SCHEMBL7329117 | 0.85 | CTSS (0.34) | RENCTSS | |
| SCHEMBL7332535 | 0.83 | F2 (0.35) | TSHRCA12CA9AGTR2CA1 | |
| SCHEMBL7333972 | 0.79 | TSHR (0.35) | TSHRALDH1A1RENF2 | |
| SCHEMBL7341341 | 0.79 | ALDH1A1 (0.36) | TSHRALDH1A1REN | |
| SCHEMBL7339274 | 0.79 | TSHR (0.34) | TSHRCA12CA9CA1REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5332742-A | Ocular hypotensive | ABBOTT LABORATORIES (US) | 1994-07-26 | — | — | US | disclosed |
| US-5310740-A | Congestive heart failure, hypotensive agents, antiglaucoma agents; side effect reduction | ABBOTT LABORATORIES (US) | 1994-05-10 | — | — | US | disclosed |
| US-5284849-A | Treating hypertension and congestive heart failure | ABBOTT LABORATORIES (US) | 1994-02-08 | — | — | US | disclosed |
| EP-0456185-A2 | Renin inhibitors | ABBOTT LABORATORIES (US) | 1991-11-13 | — | — | EP | disclosed |