Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 3/20 | 0.35 |
| ▸ | GRK3 | P35626 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | GRK5 | P34947 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6777103 | 0.88 | ITGB1 (0.38) | KMT2AMEN1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL7342958 | 0.80 | KMT2A (0.41) | KMT2AMEN1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL6783445 | 0.79 | KMT2A (0.40) | KMT2AMEN1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL7343782 | 0.78 | ALDH1A1 (0.39) | KMT2AMEN1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL6777356 | 0.76 | ITGB1 (0.42) | SMN1; SMN2GAANPC1RAB9AGPR139 | |
| SCHEMBL6776736 | 0.76 | NAMPT (0.48) | KMT2AMEN1ALDH1A1NPC1TP53 | |
| SCHEMBL27485848 | 0.74 | LMNA (0.48) | KMT2AMEN1ALDH1A1NPC1TP53 | |
| SCHEMBL27485163 | 0.72 | KDM4E (0.35) | KMT2AMEN1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL6776712 | 0.68 | KDM4E (0.41) | KMT2AMEN1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL6777100 | 0.67 | ITGB3 (0.43) | KMT2AMEN1SMN1; SMN2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | disclosed |