Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 known ✓ | P00734 | 4/20 | 0.47 |
| ▸ | PLAU | P00749 | 13/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.47 |
| ▸ | PLG | P00747 | 4/20 | 0.47 |
| ▸ | KLK1 | P06870 | 4/20 | 0.47 |
| ▸ | PLAT | P00750 | 3/20 | 0.44 |
| ▸ | PTGIR | P43119 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7337592 | 0.93 | PLAU (0.60) | PLAUPRSS1F2PLGKLK1 | |
| SCHEMBL7339139 | 0.73 | TOP2A (0.34) | PLAUPRSS1F2TP53MAPT | |
| SCHEMBL7334924 | 0.73 | PLAU (0.58) | PLAUPRSS1F2PLGKLK1 | |
| SCHEMBL7332318 | 0.72 | MAPT (0.58) | PLAUPRSS1MAPTNPC1GAA | |
| SCHEMBL7338672 | 0.72 | PLAU (1.00) | PLAUPRSS1F2PLGKLK1 | |
| SCHEMBL7344706 | 0.70 | PLAU (0.87) | PLAUPRSS1F2PLGKLK1 | |
| SCHEMBL7332586 | 0.70 | PRSS1 (0.59) | PLAUPRSS1F2PLGKLK1 | |
| SCHEMBL7332581 | 0.70 | MEN1 (0.56) | PLAUPRSS1F2PLATMAPT | |
| SCHEMBL9547457 | 0.70 | PRSS1 (0.78) | PRSS1 | |
| SCHEMBL7337538 | 0.69 | PLAU (0.68) | PLAUPRSS1F2PLGKLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6284796-B1 | NAPHTHAMIDINE COMPOUNDS | ABBOTT LABORATORIES | 2001-09-04 | — | — | US | disclosed |