⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11740637 | 0.75 | — | — | |
| SCHEMBL13673054 | 0.74 | CHRNB2 (0.31) | — | |
| SCHEMBL7077560 | 0.70 | MEN1 (0.31) | — | |
| SCHEMBL11673802 | 0.69 | — | — | |
| SCHEMBL3263886 | 0.67 | GABRP (0.31) | — | |
| SCHEMBL3067487 | 0.67 | — | — | |
| SCHEMBL21753569 | 0.67 | POLB (0.32) | — | |
| SCHEMBL166936 | 0.67 | — | — | |
| SCHEMBL166935 | 0.67 | — | — | |
| SCHEMBL9740779 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6432944-B1 | ARYLACETAMIDOALANYL DERIVATIVES OF BENZODIAZEPINONES ARE USEFUL FOR INHIBITION OF EXTRACELLULAR DEPOSITION OF BETA-AMYLOID PEPTIDE, THUS TREATS AMYLOIDOSIS, ALZHEIMER'S DISEASE AND DOWN'S SYNDROME | BRISTOL-MYERS SQUIBB COMPANY | 2002-08-13 | — | — | US | disclosed |
| US-20020022621-A1 | Benzodiazepinone beta -amyloid inhibitors: arylacetamidoalanyl derivatives | BRISTOL-MYERS SQUIBB COMPANY | 2002-02-21 | — | — | US | disclosed |