Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 7/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CTSV | O60911 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7346877 | 0.94 | GPR139 (0.41) | GPR139NOD2PTGS2KLKB1TP53 | |
| SCHEMBL7839115 | 0.90 | GPR139 (0.38) | GPR139NOD2PTGS2KLKB1TP53 | |
| SCHEMBL7347630 | 0.89 | GPR139 (0.42) | GPR139MEN1KMT2AATM | |
| SCHEMBL7825812 | 0.85 | TP53 (0.39) | NOD2TP53CTSVCTSLCTSB | |
| SCHEMBL7348747 | 0.84 | GPR139 (0.44) | GPR139MEN1KMT2AATM | |
| SCHEMBL6778050 | 0.82 | GPR139 (0.39) | GPR139TP53KDM4EEPHX2 | |
| SCHEMBL7341105 | 0.81 | CTSL (0.46) | GPR139PTGS2TP53CTSVCTSL | |
| SCHEMBL7834975 | 0.81 | EGFR (0.37) | GPR139NOD2PTGS2TP53MEN1 | |
| SCHEMBL7833181 | 0.81 | RHOC (0.40) | GPR139TP53SMN1; SMN2MEN1KMT2A | |
| SCHEMBL7825718 | 0.80 | TP53 (0.47) | GPR139NOD2TP53MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |