SCHEMBL7339537

SCHEMBL7339537

CN1CCN(CC(=O)N(c2ccccc2)c2ccc(N)cc2)CC1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CACNA2D1 P54289 7/20 0.56
CACNA1B Q00975 7/20 0.56
CACNB1 Q02641 7/20 0.56
CACNA1C Q13936 7/20 0.56
ALDH1A1 P00352 5/20 0.51
LMNA P02545 4/20 0.51
TP53 P04637 1/20 0.51
TSHR P16473 2/20 0.47
HTT P42858 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
KDM4E B2RXH2 1/20 0.46
NPC1 O15118 1/20 0.45
RAB9A P51151 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
DRD4 P21917 1/20 0.44
KMT2A Q03164 1/20 0.44
CHRM4 P08173 1/20 0.44
CHRM5 P08912 1/20 0.44
CHRM1 P11229 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7347657 0.94 LMNA (0.49) CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1
SCHEMBL7339023 0.92 CACNA2D1 (0.65) CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1
SCHEMBL7340694 0.86 MAPT (0.44) CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1
SCHEMBL7337565 0.85 CACNA2D1 (0.50) CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1
SCHEMBL7342475 0.84 CACNA2D1 (0.54) CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1
SCHEMBL7339969 0.84 CACNA2D1 (0.51) CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1
SCHEMBL7343072 0.84 CACNA2D1 (0.53) CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1
Hydrochloric Acid SCHEMBL7341072 0.83 CACNA2D1 (0.53) CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1
SCHEMBL7339671 0.83 CACNA2D1 (0.53) CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1
SCHEMBL7346027 0.83 CACNA2D1 (0.53) CACNA2D1CACNA1BCACNB1CACNA1CALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0658157-A1 DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS MERRELL PHARMACEUTICALS INC. (US) 1995-06-21 EP claimed
WO-1994005648-A1 DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS MERRELL DOW PHARMACEUTICALS INC. (US) 1994-03-17 WO claimed
EP-0585500-A1 Diaryl piperazineacetamides as antimuscarinic agents MERRELL DOW PHARMACEUTICALS INC. (US) 1994-03-09 EP claimed
EP-0658157-A1 DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS MERRELL PHARMACEUTICALS INC. (US) 1995-06-21 EP disclosed
WO-1994005648-A1 DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS MERRELL DOW PHARMACEUTICALS INC. (US) 1994-03-17 WO disclosed
EP-0585500-A1 Diaryl piperazineacetamides as antimuscarinic agents MERRELL DOW PHARMACEUTICALS INC. (US) 1994-03-09 EP disclosed