SCHEMBL7340694

SCHEMBL7340694

COc1ccc(N(C(=O)CN2CCN(C)CC2)c2ccc(N)cc2)cc1

nearest known ligand 0.45

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.44
PPIB P23284 1/20 0.44
ALDH1A1 P00352 7/20 0.43
LMNA P02545 3/20 0.43
KDM4E B2RXH2 2/20 0.43
CACNA2D1 P54289 1/20 0.41
CACNA1B Q00975 1/20 0.41
CACNB1 Q02641 1/20 0.41
CACNA1C Q13936 1/20 0.41
HTT P42858 1/20 0.41
ESR1 P03372 1/20 0.41
PDGFRB P09619 1/20 0.41
KDR P35968 1/20 0.41
POLB P06746 2/20 0.41
TP53 P04637 1/20 0.40
MAPK1 P28482 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7346581 0.94 MAPT (0.49) MAPTALDH1A1LMNAKDM4ECACNA2D1
SCHEMBL7347657 0.91 LMNA (0.49) MAPTALDH1A1LMNAKDM4ECACNA2D1
SCHEMBL7339537 0.86 CACNA2D1 (0.56) ALDH1A1LMNAKDM4ECACNA2D1CACNA1B
SCHEMBL7341561 0.85 RNF4 (0.46) MAPTPPIBALDH1A1LMNAKDM4E
SCHEMBL7348298 0.82 POLB (0.45) MAPTALDH1A1LMNAKDM4EHTT
SCHEMBL436539 0.79 DRD4 (0.50) MAPTALDH1A1LMNAKDM4EPDGFRB
SCHEMBL7346138 0.78 CACNA2D1 (0.49) ALDH1A1LMNAKDM4ECACNA2D1CACNA1B
SCHEMBL7347118 0.78 CACNA2D1 (0.49) MAPTALDH1A1LMNAKDM4ECACNA2D1
SCHEMBL7349932 0.78 LMNA (0.52) ALDH1A1LMNACACNA2D1CACNA1BCACNB1
SCHEMBL7347840 0.78 MAPT (0.50) MAPTALDH1A1LMNAKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0658157-A1 DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS MERRELL PHARMACEUTICALS INC. (US) 1995-06-21 EP claimed
WO-1994005648-A1 DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS MERRELL DOW PHARMACEUTICALS INC. (US) 1994-03-17 WO claimed
EP-0648240-A1 PROCESS FOR THE MODIFICATION OF POLYPHENYLENE ETHER RESIN COMPOSITIONS Akzo Nobel N.V. (NL) 1995-04-19 EP disclosed
EP-0495545-B1 Citraconimide (co)polymers and curing with anionic catalyst AKZO NOBEL NV (NL) 1994-12-28 EP disclosed
EP-0585500-A1 Diaryl piperazineacetamides as antimuscarinic agents MERRELL DOW PHARMACEUTICALS INC. (US) 1994-03-09 EP disclosed
WO-1994001485-A1 PROCESS FOR THE MODIFICATION OF POLYPHENYLENE ETHER RESIN COMPOSITIONS AKZO NOBEL N.V. (NL) 1994-01-20 WO disclosed
US-5221717-A CITRACONIMIDE (CO)POLYMERS AND CURING WITH ANIONIC CATALYST AKZO N.V. (NL) 1993-06-22 US disclosed
EP-0495545-A1 Citraconimide (co)polymers and curing with anionic catalyst Akzo Nobel N.V. (NL) 1992-07-22 EP disclosed