Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | CACNA2D1 | P54289 | 7/20 | 0.48 |
| ▸ | CACNA1B | Q00975 | 7/20 | 0.48 |
| ▸ | CACNB1 | Q02641 | 7/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7339537 | 0.94 | CACNA2D1 (0.56) | LMNACACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL7340694 | 0.91 | MAPT (0.44) | LMNACACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL436539 | 0.87 | DRD4 (0.50) | LMNAALDH1A1KDM4EKMT2AGAA | |
| SCHEMBL7346138 | 0.86 | CACNA2D1 (0.49) | LMNACACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL7347118 | 0.86 | CACNA2D1 (0.49) | LMNACACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL7339023 | 0.84 | CACNA2D1 (0.65) | LMNACACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL7346581 | 0.82 | MAPT (0.49) | LMNACACNA2D1CACNA1BCACNB1CACNA1C | |
| SCHEMBL27959324 | 0.82 | LMNA (0.43) | LMNAADRA2C | |
| SCHEMBL4490990 | 0.82 | DRD4 (0.46) | LMNANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28073437 | 0.80 | DRD4 (0.42) | LMNAALDH1A1KDM4ETSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0658157-A1 | DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1995-06-21 | — | — | EP | claimed |
| WO-1994005648-A1 | DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-03-17 | — | — | WO | claimed |
| EP-0658157-A1 | DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1995-06-21 | — | — | EP | disclosed |
| WO-1994005648-A1 | DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-03-17 | — | — | WO | disclosed |
| EP-0585500-A1 | Diaryl piperazineacetamides as antimuscarinic agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-03-09 | — | — | EP | disclosed |