Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | PDE9A | O76083 | 2/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | GALR3 | O60755 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | FASN | P49327 | 3/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7339417 | 0.80 | PARP1 (0.47) | KDM4EALDH1A1PDE9ALMNAPARP1 | |
| SCHEMBL7340847 | 0.80 | DYRK1A (0.49) | KDM4ELMNACLK1DYRK1APARP1 | |
| SCHEMBL29890500 | 0.78 | BRD4 (0.55) | KDM4EALDH1A1PDE9AMCL1LMNA | |
| SCHEMBL1903750 | 0.78 | BRD4 (0.55) | KDM4EALDH1A1PDE9AMCL1LMNA | |
| SCHEMBL7338498 | 0.77 | PARP1 (0.47) | KDM4EPDE9ALMNAPARP1HPGD | |
| SCHEMBL7339379 | 0.76 | PARP1 (0.57) | KDM4EALDH1A1LMNAHSD17B10PARP1 | |
| SCHEMBL7341095 | 0.76 | DAO (0.61) | KDM4EALDH1A1LMNAHSD17B10PARP1 | |
| SCHEMBL9535550 | 0.74 | ALDH1A1 (0.53) | KDM4EALDH1A1PDE9AMCL1HSD17B10 | |
| SCHEMBL10964698 | 0.74 | DPYD (0.38) | KDM4EALDH1A1PDE9AMCL1LMNA | |
| SCHEMBL3335454 | 0.73 | DAO (0.59) | KDM4EALDH1A1PDE9ALMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511569-A | Tricyclic lactams and derivatives useful in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-04-16 | — | — | US | claimed |
| US-4511569-A | Tricyclic lactams and derivatives useful in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-04-16 | — | — | US | disclosed |
| EP-0102046-A1 | Tricyclic lactams, method for making them, pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-03-07 | — | — | EP | disclosed |