Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6970062 | 1.00 | KMT2A (0.39) | KMT2APOLBMAPTL3MBTL1MEN1 | |
| SCHEMBL13754293 | 0.75 | MAPT (0.48) | KMT2APOLBMAPTL3MBTL1MEN1 | |
| SCHEMBL6970033 | 0.74 | L3MBTL1 (0.64) | KMT2APOLBMAPTL3MBTL1MEN1 | |
| Dimethylamine SCHEMBL11267691 | 0.74 | MEN1 (0.44) | KMT2APOLBMAPTL3MBTL1MEN1 | |
| SCHEMBL30860765 | 0.73 | PTGS1 (0.44) | KMT2APOLBMAPTL3MBTL1MEN1 | |
| SCHEMBL22549409 | 0.71 | MEN1 (0.39) | KMT2APOLBMAPTL3MBTL1MEN1 | |
| SCHEMBL6422411 | 0.69 | HPGD (0.34) | KMT2AMEN1PKMHPGD | |
| SCHEMBL28498453 | 0.69 | NQO2 (0.40) | KMT2APOLBMAPTL3MBTL1MEN1 | |
| SCHEMBL16372578 | 0.68 | CYP3A4 (0.49) | KMT2APOLBMAPTL3MBTL1MEN1 | |
| SCHEMBL21591954 | 0.67 | MAPT (0.44) | KMT2APOLBMAPTL3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819125-A1 | THIENYL-, FURYL-, PYRROLYL- AND BIPHENYLSULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1998-01-21 | — | — | EP | disclosed |
| WO-1996031492-A1 | THIENYL-, FURYL-, PYRROLYL- AND BIPHENYLSULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1996-10-10 | — | — | WO | disclosed |