Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCAT2 | O15382 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 3/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7339006 | 0.88 | NOTUM (0.44) | BCAT2SRD5A2BRD4CHEK1AURKA | |
| SCHEMBL7336750 | 0.87 | CYP1A2 (0.36) | HTR2BHTR7DRD2ADRA1DHTR2A | |
| SCHEMBL7346248 | 0.81 | SIRT3 (0.41) | KDM4E | |
| SCHEMBL7346618 | 0.80 | AURKA (0.36) | AURKAPARP1CSNK1A1TYRO3DYRK1B | |
| SCHEMBL7347685 | 0.78 | PDE3B (0.45) | HTR2BHTR7DRD2ADRA1DHTR2A | |
| SCHEMBL7348959 | 0.78 | CSNK1A1 (0.39) | BCAT2PARP1CSNK1A1TYRO3DYRK1B | |
| SCHEMBL11071902 | 0.77 | MAOA (0.44) | BCAT2BRD4AURKAPARP1MAOA | |
| Hydrochloric Acid SCHEMBL11073271 | 0.76 | MAOA (0.42) | BCAT2HTR2BHTR7BRD4AURKA | |
| SCHEMBL11071180 | 0.76 | ACHE (0.41) | BCAT2BRD4CHEK1AURKAPARP1 | |
| SCHEMBL7342355 | 0.75 | CES1 (0.40) | SRD5A2PARP1ADORA2AKDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511569-A | Tricyclic lactams and derivatives useful in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-04-16 | — | — | US | disclosed |
| EP-0102046-A1 | Tricyclic lactams, method for making them, pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-03-07 | — | — | EP | disclosed |