Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.35 |
| ▸ | ITGAV | P06756 | 2/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6778093 | 0.89 | LMNA (0.43) | LMNAITGB3ITGAVITGA2BCCR2 | |
| SCHEMBL7340265 | 0.76 | ABCB1 (0.41) | LMNAALDH1A1SMN1; SMN2HPGDMAPT | |
| SCHEMBL7343450 | 0.75 | ITGB3 (0.36) | LMNAITGB3ITGAVITGA2BALDH1A1 | |
| SCHEMBL7346999 | 0.74 | ITGB3 (0.52) | ITGB3ITGAVITGA2BALDH1A1SMN1; SMN2 | |
| SCHEMBL7338324 | 0.73 | ITGB3 (0.46) | LMNAITGB3ITGAVITGA2BALDH1A1 | |
| SCHEMBL6777064 | 0.73 | ITGB3 (0.46) | LMNAITGB3ITGAVITGA2BALDH1A1 | |
| SCHEMBL7349786 | 0.73 | ITGB3 (0.45) | LMNAITGB3ITGAVITGA2BALDH1A1 | |
| SCHEMBL7837513 | 0.73 | NPC1 (0.38) | LMNAALDH1A1SMN1; SMN2MAPTGPR139 | |
| SCHEMBL7349108 | 0.71 | ITGB3 (0.38) | ITGB3ITGAVITGA2BALDH1A1SENP1 | |
| SCHEMBL7348335 | 0.71 | ITGB3 (0.41) | LMNAITGB3ITGAVITGA2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |