Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 8/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CDC25B | P30305 | 1/20 | 0.35 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.35 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.35 |
| ▸ | PTAFR | P25105 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7340324 | 0.81 | KDM4E (0.53) | NPY5RKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7341393 | 0.81 | KDM4E (0.39) | NPY5RKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7347592 | 0.73 | MAPK14 (0.39) | PTAFRMEN1KMT2AMAPK14LMNA | |
| SCHEMBL7336559 | 0.73 | KDM4E (0.46) | KDM4EALDH1A1HPGDHSD17B10PTAFR | |
| SCHEMBL9541706 | 0.70 | L3MBTL1 (0.45) | NPY5RPTAFRCHRM2HTR1ACHRM1 | |
| SCHEMBL4912110 | 0.69 | TSHR (0.43) | NPY5RKDM4ECDC25BPTAFRMEN1 | |
| SCHEMBL9542103 | 0.69 | PARP10 (0.41) | NPY5RCDC25BPTAFRMEN1KMT2A | |
| SCHEMBL6475329 | 0.69 | GRM4 (0.49) | NPY5RKCNH2 | |
| SCHEMBL11092286 | 0.69 | AURKB (0.38) | CDC25BMEN1KMT2AMAPK14TDP2 | |
| SCHEMBL4786314 | 0.68 | ALDH1A1 (0.58) | KDM4EALDH1A1HPGDHSD17B10CDC25B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511569-A | Tricyclic lactams and derivatives useful in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-04-16 | — | — | US | disclosed |
| EP-0102046-A1 | Tricyclic lactams, method for making them, pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-03-07 | — | — | EP | disclosed |