SCHEMBL9541706

SCHEMBL9541706

Brc1ccc2c(c1)-c1ncccc1CCC2

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.45
TDP1 Q9NUW8 1/20 0.45
PTAFR P25105 3/20 0.43
PARP1 P09874 1/20 0.41
PARP10 Q53GL7 1/20 0.41
CCNB2 O95067 1/20 0.40
CDK1 P06493 1/20 0.40
CCNB1 P14635 1/20 0.40
CCNB3 Q8WWL7 1/20 0.40
CYP1A2 P05177 1/20 0.39
CYP2C19 P33261 1/20 0.39
HTT P42858 1/20 0.39
CHRM2 P08172 1/20 0.38
HTR1A P08908 1/20 0.38
CHRM1 P11229 1/20 0.38
DRD2 P14416 1/20 0.38
HTR2A P28223 1/20 0.38
HTR2C P28335 1/20 0.38
ADRA1A P35348 1/20 0.38
HRH1 P35367 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3900928 0.79 NPY5R (0.53) L3MBTL1PTAFRCHRM2HTR1ACHRM1
SCHEMBL4912110 0.76 TSHR (0.43) L3MBTL1TDP1PTAFRCHRM2HTR1A
SCHEMBL23264456 0.75 L3MBTL1 (0.62) L3MBTL1TDP1PARP1PARP10CCNB2
SCHEMBL28722279 0.75 TSHR (0.52) L3MBTL1TDP1PTAFRCHRM2HTR1A
SCHEMBL9542103 0.73 PARP10 (0.41) L3MBTL1TDP1PTAFRPARP10CHRM2
SCHEMBL17427081 0.71 CYP2C19 (0.41) TDP1PTAFRCYP1A2CYP2C19HTT
SCHEMBL31317931 0.71 HRH1 (0.58) TDP1PTAFRCHRM2HTR1ACHRM1
SCHEMBL730635 0.71 HRH1 (0.58) TDP1PTAFRCHRM2HTR1ACHRM1
SCHEMBL7340286 0.70 NPY5R (0.40) TDP1PTAFRPARP1CHRM2HTR1A
SCHEMBL15240550 0.70 ROCK2 (0.46) L3MBTL1TDP1PTAFRCYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1993014080-A1 BRIDGED HETEROCYCLIC FUNGICIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-07-22 WO disclosed