Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7346004 | 0.86 | TSHR (0.43) | NPC1RAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL1029640 | 0.86 | HPGD (0.50) | HPGDALDH1A1SMN1; SMN2ERCC5FEN1 | |
| SCHEMBL7340295 | 0.79 | HPGD (0.40) | NPC1RAB9AHPGDALDH1A1SMN1; SMN2 | |
| Chlorobenzene SCHEMBL28513506 | 0.77 | TSHR (0.44) | NPC1RAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL93382 | 0.73 | ALDH1A1 (0.54) | HPGDALDH1A1SMN1; SMN2ERCC5FEN1 | |
| SCHEMBL5426379 | 0.73 | TSHR (0.43) | NPC1RAB9AHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL29677294 | 0.73 | ALDH1A1 (0.54) | HPGDALDH1A1SMN1; SMN2ERCC5FEN1 | |
| Ammonia Solution, Strong SCHEMBL27608787 | 0.71 | ALDH1A1 (0.52) | HPGDALDH1A1SMN1; SMN2ERCC5FEN1 | |
| SCHEMBL9538691 | 0.70 | TRPA1 (0.44) | NPC1RAB9AHPGDALDH1A1HTT | |
| SCHEMBL8846398 | 0.70 | HPGD (0.47) | HPGDALDH1A1SMN1; SMN2ERCC5FEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996007648-A1 | 2-SUBSTITUTED-4H-3,1-BENZOXAZIN-4-ONES AND BENZTHIAZIN-4-ONES AS INHIBITORS OF COMPLEMENT Clr PROTEASE FOR THE TREATMENT OF INFLAMMATORY PROCESSES | WARNER-LAMBERT COMPANY (US) | 1996-03-14 | — | — | WO | disclosed |