Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 11/20 | 0.50 |
| ▸ | CA9 | Q16790 | 11/20 | 0.50 |
| ▸ | CA2 | P00918 | 7/20 | 0.47 |
| ▸ | CA1 | P00915 | 7/20 | 0.47 |
| ▸ | CA7 | P43166 | 5/20 | 0.46 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | CA6 | P23280 | 2/20 | 0.44 |
| ▸ | CA5A | P35218 | 2/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20437010 | 0.90 | PTPN11 (0.48) | CA12CA9CA2CA1KMT2A | |
| SCHEMBL11681555 | 0.88 | CA12 (0.53) | CA12CA9CA2CA1CA7 | |
| SCHEMBL20423635 | 0.82 | CA12 (0.47) | CA12CA9CA2CA1CA7 | |
| SCHEMBL20423830 | 0.80 | CA12 (0.45) | CA12CA9CA2CA1CA7 | |
| SCHEMBL5186168 | 0.80 | CA12 (0.63) | CA12CA9CA2CA1CA7 | |
| SCHEMBL9814730 | 0.77 | MAOB (0.59) | CA12CA9CA2CA1CA7 | |
| SCHEMBL20443154 | 0.76 | CA12 (0.57) | CA12CA9CA2CA1CA7 | |
| SCHEMBL9825762 | 0.74 | CA12 (0.54) | CA12CA9CA2CA1CA7 | |
| SCHEMBL7284252 | 0.73 | MAOA (0.63) | CA12CA9CA2CA1CA7 | |
| SCHEMBL29349483 | 0.71 | CA12 (0.62) | CA12CA9CA2CA1CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | disclosed |
| EP-0811001-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1997-12-10 | — | — | EP | disclosed |
| US-5599811-A | PHENYL OR DIOXYPHENYL SUBSTITUENTS; DRUGS | WARNER-LAMBERT COMPANY (US) | 1997-02-04 | — | — | US | disclosed |
| WO-1996026195-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-08-29 | — | — | WO | disclosed |