Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 2/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.46 |
| ▸ | ERN1 | O75460 | 2/20 | 0.46 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MDH2 | P40926 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL186998 | 0.85 | IMPDH2 (0.43) | IMPDH2CYP2A6MAPTSMN1; SMN2NPC1 | |
| SCHEMBL187332 | 0.85 | MAPT (0.44) | CTSVCTSLERN1IMPDH2CYP2A6 | |
| SCHEMBL187798 | 0.84 | CTSV (0.56) | CTSVCTSLERN1IMPDH2CYP2A6 | |
| SCHEMBL7823652 | 0.84 | CTSV (0.56) | CTSVCTSLERN1IMPDH2CYP2A6 | |
| SCHEMBL29957099 | 0.82 | MAPT (0.44) | CTSVCTSLERN1IMPDH2CYP2A6 | |
| SCHEMBL856019 | 0.81 | ERN1 (0.55) | ERN1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL31113771 | 0.80 | ERN1 (0.54) | ERN1MAPTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL1418239 | 0.78 | IMPDH2 (0.61) | CTSVCTSLIMPDH2CYP2A6MAPT | |
| SCHEMBL29951517 | 0.78 | IMPDH2 (0.61) | CTSVCTSLIMPDH2CYP2A6MAPT | |
| SCHEMBL1791105 | 0.78 | MEN1 (0.60) | IMPDH2MAPTSMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0505322-B1 | Aminoguanidines | CIBA GEIGY AG (CH) | 1998-09-09 | — | — | EP | disclosed |
| US-5510353-A | TREATING IRRITABLE BOWEL SYNDROME, GASTROESOPHAGEAL REFLUX DISEASE, CONSTIPATION, MIGRAINE HEADACHES | SANDOZ LTD. (CH) | 1996-04-23 | — | — | US | disclosed |
| EP-0505322-A1 | Aminoguanidines | SANDOZ LTD. (CH) | 1992-09-23 | — | — | EP | disclosed |