Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSV | O60911 | 2/20 | 0.56 |
| ▸ | CTSL | P07711 | 2/20 | 0.56 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | ERN1 | O75460 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.43 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL187798 | 1.00 | CTSV (0.56) | CTSVCTSLSRD5A1SRD5A2ERN1 | |
| SCHEMBL29957099 | 0.86 | MAPT (0.44) | CTSVCTSLERN1ALDH1A1MAPT | |
| SCHEMBL187332 | 0.86 | MAPT (0.44) | CTSVCTSLERN1ALDH1A1MAPT | |
| SCHEMBL186998 | 0.84 | IMPDH2 (0.43) | ALDH1A1MAPTCYP1A2CYP2C19KDM4E | |
| SCHEMBL7340451 | 0.84 | CTSV (0.46) | CTSVCTSLSRD5A2ERN1ALDH1A1 | |
| SCHEMBL3034534 | 0.83 | ALDH1A1 (0.61) | ALDH1A1MAPTCYP1A2CYP2C19KDM4E | |
| SCHEMBL17067000 | 0.82 | CTSV (0.58) | CTSVCTSLSRD5A1SRD5A2ALDH1A1 | |
| SCHEMBL15730198 | 0.82 | CTSV (0.57) | CTSVCTSLSRD5A1SRD5A2ALDH1A1 | |
| SCHEMBL18474478 | 0.82 | CTSV (0.57) | CTSVCTSLSRD5A1SRD5A2ALDH1A1 | |
| SCHEMBL18975225 | 0.81 | SRD5A1 (0.60) | CTSVCTSLSRD5A1SRD5A2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0680950-B1 | PROPENONE DERIVATIVES | KYOWA HAKKO KOGYO KK (JP) | 2001-05-23 | — | — | EP | disclosed |
| US-5952355-A | 1-ETHER-SUBSTITUTED PHENYL-3-INDOL-3-YL-2-PROPEN-1-ONE DERIVATIVES; ANTITUMOR AND -CARCINOGENIC AGENTS; IMMUNOSUPPRESSANTS; AUTOIMMUNE DISEASES; SIDE EFFECT REDUCTION | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1999-09-14 | — | — | US | disclosed |
| EP-0680950-A1 | PROPENONE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1995-11-08 | — | — | EP | disclosed |