Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | APEX1 | P27695 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7340327 | 0.91 | SMN1; SMN2 (0.57) | HSD17B10SMN1; SMN2POLBAPEX1TDP1 | |
| SCHEMBL7343940 | 0.89 | ALDH1A1 (0.54) | HSD17B10SMN1; SMN2POLBAPEX1TDP1 | |
| SCHEMBL10767291 | 0.85 | SMN1; SMN2 (0.50) | HSD17B10SMN1; SMN2POLBAPEX1TDP1 | |
| SCHEMBL11000826 | 0.84 | ALDH1A1 (0.63) | HSD17B10SMN1; SMN2POLBAPEX1TDP1 | |
| SCHEMBL7346924 | 0.84 | CYP1A2 (0.57) | HSD17B10TSHRALDH1A1GAAHPGD | |
| SCHEMBL30855594 | 0.84 | CYP1A2 (0.57) | HSD17B10TSHRALDH1A1GAAHPGD | |
| SCHEMBL10495293 | 0.84 | SMN1; SMN2 (0.67) | HSD17B10SMN1; SMN2POLBAPEX1TDP1 | |
| SCHEMBL29500204 | 0.83 | SMN1; SMN2 (0.65) | HSD17B10SMN1; SMN2POLBAPEX1TDP1 | |
| SCHEMBL20176018 | 0.82 | TSHR (0.67) | HSD17B10SMN1; SMN2POLBAPEX1TDP1 | |
| SCHEMBL7747787 | 0.80 | SMN1; SMN2 (0.61) | HSD17B10SMN1; SMN2POLBAPEX1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5258519-A | FOR TREATMENT OF HYPERTENSION AND CARDIAC CONDITIONS | GLAXO INC. (US) | 1993-11-02 | — | — | US | disclosed |
| US-5100892-A | Hypotensive agents, congestive heart failure | GLAXO INC. (US) | 1992-03-31 | — | — | US | disclosed |
| US-4833150-A | HYPOTENSIVES, ANTIARRHYTHMIA AGENTS | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1989-05-23 | — | — | US | disclosed |
| US-4652573-A | HYPOTENSIVE AGENTS | NELSON RESEARCH & DEVELOPMENT CO. (US) | 1987-03-24 | — | — | US | disclosed |
| EP-0194685-A1 | 1,4-Dihydropyridines | Whitby Research Incorporated (US) | 1986-09-17 | — | — | EP | disclosed |