Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.37 |
| ▸ | ITGAV | P06756 | 1/20 | 0.37 |
| ▸ | ITGB6 | P18564 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4336179 | 0.85 | SMN1; SMN2 (0.41) | SMN1; SMN2LMNAMAPTALDH1A1MEN1 | |
| SCHEMBL7347348 | 0.80 | KMT2A (0.38) | SMN1; SMN2LMNAMAPTALDH1A1MEN1 | |
| SCHEMBL7369754 | 0.80 | ITGB1 (0.48) | SMN1; SMN2LMNAMAPTMEN1KMT2A | |
| SCHEMBL7338744 | 0.80 | LMNA (0.46) | NPC1RAB9ASMN1; SMN2LMNAMAPT | |
| SCHEMBL7349856 | 0.78 | ITGB3 (0.46) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7343848 | 0.78 | SMN1; SMN2 (0.38) | SMN1; SMN2LMNAMAPTALDH1A1MEN1 | |
| SCHEMBL7343852 | 0.78 | SMN1; SMN2 (0.38) | SMN1; SMN2LMNAMAPTALDH1A1MEN1 | |
| SCHEMBL7338107 | 0.77 | ITGB3 (0.40) | SMN1; SMN2LMNAMAPTALDH1A1MEN1 | |
| SCHEMBL7367429 | 0.77 | ITGB3 (0.62) | ITGB3ITGAVITGB6 | |
| SCHEMBL6774120 | 0.77 | ITGB3 (0.47) | ITGB3ITGAVITGB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |