Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4360565 | 0.86 | CHRM2 (0.52) | ALDH1A1EPHX1HPGD | |
| SCHEMBL31657251 | 0.85 | KDM4E (0.46) | GPR119ALDH1A1EPHX1PTPN2PTPN1 | |
| SCHEMBL25329388 | 0.84 | ALDH1A1 (0.44) | ALDH1A1EPHX1PTPN2PTPN1PTPN6 | |
| SCHEMBL310117 | 0.83 | GPR119 (0.67) | GPR119EPHX1HPGDRECQL | |
| SCHEMBL7360145 | 0.82 | ALDH1A1 (0.42) | GPR119ALDH1A1EPHX1PTPN2PTPN1 | |
| SCHEMBL27345518 | 0.82 | GPR119 (0.56) | GPR119EPHX1PTPN2PTPN1PTPN6 | |
| SCHEMBL13274147 | 0.81 | GPR119 (0.65) | GPR119EPHX1HPGDRECQL | |
| SCHEMBL21068971 | 0.80 | CYP2D6 (0.50) | GPR119ALDH1A1 | |
| SCHEMBL29030966 | 0.79 | NR1H2 (0.54) | ALDH1A1EPHX1HPGD | |
| SCHEMBL27340690 | 0.79 | GPR119 (0.53) | GPR119EPHX1PTPN2PTPN1PTPN6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0767792-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-11-20 | — | — | EP | disclosed |
| US-5977101-A | Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0767792-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-04-16 | — | — | EP | disclosed |
| WO-1996000730-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1996-01-11 | — | — | WO | disclosed |