Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.47 |
| ▸ | CCND1 | P24385 | 1/20 | 0.47 |
| ▸ | PARP1 | P09874 | 5/20 | 0.45 |
| ▸ | DAO | P14920 | 2/20 | 0.45 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.42 |
| ▸ | CHUK | O15111 | 3/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7348155 | 0.80 | DAO (0.44) | CDK4CCND1PARP1DAOBRAF | |
| SCHEMBL7340847 | 0.78 | DYRK1A (0.49) | CDK4CCND1PARP1DAOLMNA | |
| SCHEMBL7339379 | 0.78 | PARP1 (0.57) | PARP1LMNACYP1A2 | |
| SCHEMBL7346243 | 0.74 | TYMS (0.50) | PARP1DAOLMNACYP1A2 | |
| SCHEMBL10812608 | 0.70 | PDE3B (0.60) | PARP1CYP1A2CYP3A4CYP2D6PDE3B | |
| SCHEMBL7346958 | 0.70 | PARP1 (0.41) | PARP1DAOLMNACYP1A2CYP2C19 | |
| SCHEMBL445595 | 0.70 | IMPDH2 (0.58) | CDK4CCND1IMPDH2LMNACYP1A2 | |
| SCHEMBL30963037 | 0.69 | CHUK (0.65) | CDK4CCND1BRAFCHUK | |
| SCHEMBL10642567 | 0.69 | CHUK (0.65) | CDK4CCND1BRAFCHUK | |
| SCHEMBL13687857 | 0.68 | PARP1 (0.63) | PARP1IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511569-A | Tricyclic lactams and derivatives useful in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-04-16 | — | — | US | disclosed |
| EP-0102046-A1 | Tricyclic lactams, method for making them, pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-03-07 | — | — | EP | disclosed |