Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAO | P14920 | 2/20 | 0.44 |
| ▸ | CLK1 | P49759 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 5/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1207759 | 0.81 | DAO (0.62) | DAOCLK1CDK5DYRK1ACDK5R1 | |
| SCHEMBL7345844 | 0.80 | ALDH1A1 (0.55) | KDM4EPARP1TDP1 | |
| SCHEMBL7347264 | 0.80 | CDK4 (0.47) | DAOCDK4CCND1PARP1BRAF | |
| SCHEMBL35211818 | 0.79 | DAO (0.62) | DAOCLK1CDK5DYRK1ACDK5R1 | |
| SCHEMBL11095481 | 0.76 | PARP1 (0.54) | DAOKDM4EHTTPARP1TDP1 | |
| SCHEMBL7340847 | 0.74 | DYRK1A (0.49) | DAOCLK1CDK5DYRK1ACDK5R1 | |
| SCHEMBL10811949 | 0.73 | KDM4E (0.56) | DYRK1AKDM4EHTTPARP1BRAF | |
| SCHEMBL7097869 | 0.70 | SIRT3 (0.47) | CLK1CDK5DYRK1ACDK5R1KDM4E | |
| SCHEMBL26347775 | 0.70 | KDM5A (0.62) | CLK1CDK5DYRK1ACDK5R1KDM4E | |
| SCHEMBL5801279 | 0.69 | AR (0.48) | CDK5DYRK1AKDM4EHTTCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511569-A | Tricyclic lactams and derivatives useful in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-04-16 | — | — | US | disclosed |
| EP-0102046-A1 | Tricyclic lactams, method for making them, pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-03-07 | — | — | EP | disclosed |