Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 4/20 | 0.34 |
| ▸ | ITGA5 | P08648 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.33 |
| ▸ | ITGAV | P06756 | 3/20 | 0.33 |
| ▸ | MDM4 | O15151 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GRK2 | P25098 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7348232 | 0.91 | ITGB3 (0.33) | ITGB1ITGA5KMT2AITGB3ITGAV | |
| SCHEMBL7348831 | 0.90 | ITGB3 (0.33) | ITGB1ITGA5KMT2AITGB3ITGAV | |
| SCHEMBL7340934 | 0.88 | ITGB3 (0.37) | ITGB1ITGA5KMT2AITGB3ITGAV | |
| SCHEMBL7346234 | 0.82 | KMT2A (0.34) | ITGB1ITGA5KMT2AITGB3ITGAV | |
| SCHEMBL7341130 | 0.82 | KMT2A (0.35) | ITGB1ITGA5KMT2AITGB3ITGAV | |
| SCHEMBL7347263 | 0.81 | ITGB3 (0.34) | ITGB1ITGA5ITGB3ITGAVMDM4 | |
| SCHEMBL7341076 | 0.80 | SMN1; SMN2 (0.36) | KMT2AITGB3ITGAVALDH1A1ITGA2B | |
| SCHEMBL7403130 | 0.79 | HTT (0.36) | ITGB1ITGA5ITGB3ITGAVGPR139 | |
| SCHEMBL7348225 | 0.79 | ITGB3 (0.38) | ITGB1KMT2AITGB3ITGAVITGA2B | |
| SCHEMBL7348610 | 0.79 | ITGB3 (0.33) | ITGB1ITGA5KMT2AITGB3ITGAV |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |