Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 3/20 | 0.37 |
| ▸ | ITGA2B | P08514 | 3/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.34 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 2/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7348225 | 0.91 | ITGB3 (0.38) | ITGB3ITGA2BITGB1SMN1; SMN2LMNA | |
| SCHEMBL7348823 | 0.90 | ITGB3 (0.37) | ITGB3ITGA2BITGB1ITGA5SMN1; SMN2 | |
| SCHEMBL7340943 | 0.88 | ITGB1 (0.34) | ITGB3ITGA2BITGB1ITGA5SMN1; SMN2 | |
| SCHEMBL7341117 | 0.81 | ITGB3 (0.39) | ITGB3ITGA2BITGB1SMN1; SMN2LMNA | |
| SCHEMBL7346229 | 0.81 | ITGB3 (0.36) | ITGB3ITGA2BITGB1SMN1; SMN2LMNA | |
| SCHEMBL7347252 | 0.81 | ITGB3 (0.38) | ITGB3ITGA2BITGB1ITGA5SMN1; SMN2 | |
| SCHEMBL7341068 | 0.80 | ITGB3 (0.36) | ITGB3ITGA2BITGB1SMN1; SMN2LMNA | |
| SCHEMBL7348232 | 0.79 | ITGB3 (0.33) | ITGB3ITGA2BITGB1ITGA5SMN1; SMN2 | |
| SCHEMBL7348597 | 0.78 | ITGB3 (0.38) | ITGB3ITGA2BITGB1SMN1; SMN2LMNA | |
| SCHEMBL7348831 | 0.78 | ITGB3 (0.33) | ITGB3ITGA2BITGB1ITGA5SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |