Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F12 | P00748 | 12/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 8/20 | 0.50 |
| ▸ | F2 | P00734 | 8/20 | 0.50 |
| ▸ | PLG | P00747 | 7/20 | 0.50 |
| ▸ | F10 | P00742 | 3/20 | 0.50 |
| ▸ | KLK1 | P06870 | 3/20 | 0.50 |
| ▸ | C1R | P00736 | 2/20 | 0.50 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.50 |
| ▸ | MLNR | O43193 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | HPN | P05981 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.50 |
| ▸ | C1S | P09871 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nafamostat SCHEMBL29429445 | 0.84 | PRSS1 (0.64) | F12PRSS1F2PLGF10 | |
| Nafamostat SCHEMBL29429443 | 0.84 | PRSS1 (0.64) | F12PRSS1F2PLGF10 | |
| Nafamostat SCHEMBL16069975 | 0.84 | PRSS1 (0.64) | F12PRSS1F2PLGF10 | |
| Nafamostat SCHEMBL135503 | 0.84 | PRSS1 (0.64) | F12PRSS1F2PLGF10 | |
| SCHEMBL7342063 | 0.83 | F12 (0.54) | F12PRSS1F2PLGF10 | |
| Nafamostat SCHEMBL3302794 | 0.83 | PRSS1 (0.63) | F12PRSS1F2PLGF10 | |
| Nafamostat SCHEMBL7345508 | 0.82 | PRSS1 (0.62) | F12PRSS1F2PLGF10 | |
| SCHEMBL20008652 | 0.81 | F12 (0.46) | F12PRSS1F2PLGF10 | |
| SCHEMBL7341911 | 0.80 | PRSS1 (0.56) | F12PRSS1F2PLGF10 | |
| Nafamostat SCHEMBL7051240 | 0.79 | PLAU (0.58) | F12PRSS1F2PLGF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0048433-B1 | NOVEL AMIDINE COMPOUNDS, PROCESS FOR PRODUCING SAME AND ANTI-COMPLEMENT AGENT COMPRISING THEM | TORII & CO., LTD. (JP) | 1986-05-28 | — | — | EP | disclosed |
| US-4532255-A | Amidine compounds and anticomplement agent comprising same | TORII & CO., LTD. (JP) | 1985-07-30 | — | — | US | disclosed |
| US-4454338-A | 6-AMIDINO-2-NATHTHYL-4-GUANIDINOBENZOATE | TORII & CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |
| EP-0048433-A2 | Novel amidine compounds, process for producing same and anti-complement agent comprising them | TORII & CO., LTD. (JP) | 1982-03-31 | — | — | EP | disclosed |