Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F12 | P00748 | 12/20 | 0.46 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.45 |
| ▸ | F2 | P00734 | 7/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 7/20 | 0.45 |
| ▸ | PLG | P00747 | 6/20 | 0.45 |
| ▸ | PLAU | P00749 | 6/20 | 0.45 |
| ▸ | KLKB1 | P03952 | 5/20 | 0.45 |
| ▸ | F10 | P00742 | 3/20 | 0.45 |
| ▸ | PLAT | P00750 | 3/20 | 0.45 |
| ▸ | C1R | P00736 | 2/20 | 0.45 |
| ▸ | KLK1 | P06870 | 2/20 | 0.45 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.45 |
| ▸ | MLNR | O43193 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.45 |
| ▸ | HPN | P05981 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.45 |
| ▸ | C1S | P09871 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20008657 | 0.84 | FTO (0.43) | F12FTOF2PRSS1PLG | |
| SCHEMBL20008659 | 0.82 | FTO (0.49) | F12FTOF2PRSS1PLG | |
| SCHEMBL20008656 | 0.81 | FTO (0.47) | F12FTOF2PRSS1PLG | |
| SCHEMBL7341009 | 0.81 | F12 (0.50) | F12FTOF2PRSS1PLG | |
| SCHEMBL20008672 | 0.81 | KDM4E (0.40) | PRSS1KLK1TMPRSS2PRSS2PRSS3 | |
| SCHEMBL20008654 | 0.80 | FTO (0.45) | F12FTOF2PRSS1PLG | |
| Nafamostat SCHEMBL29429445 | 0.79 | PRSS1 (0.64) | F12FTOF2PRSS1PLG | |
| Nafamostat SCHEMBL135503 | 0.79 | PRSS1 (0.64) | F12FTOF2PRSS1PLG | |
| Nafamostat SCHEMBL29429443 | 0.79 | PRSS1 (0.64) | F12FTOF2PRSS1PLG | |
| Nafamostat SCHEMBL16069975 | 0.79 | PRSS1 (0.64) | F12FTOF2PRSS1PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180085366-A1 | OPIOID COMPOSITIONS RESISTANT TO OVERDOSE AND ABUSE | ELYSIUM THERAPEUTICS, INC. | 2018-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180085366-A1 | OPIOID COMPOSITIONS RESISTANT TO OVERDOSE AND ABUSE | OPRM1, OPRK1, OPRD1 | F12 3544/4885FTO 338/4885F2 3807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.