Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.38 |
| ▸ | MAOA | P21397 | 5/20 | 0.38 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 5/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | EBP | Q15125 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5807645 | 0.78 | KDM1A (0.40) | MAOBMAOABCHEADRA2BADRA2C | |
| SCHEMBL4348712 | 0.78 | MAOB (0.38) | MAOBMAOABCHEADRA2BADRA2C | |
| SCHEMBL7947368 | 0.78 | MAOB (0.41) | MAOBMAOABCHEADRA2BADRA2C | |
| SCHEMBL6277987 | 0.76 | MAOB (0.34) | MAOBMAOABCHEADRA2BADRA2C | |
| SCHEMBL1051970 | 0.71 | MAOB (0.39) | MAOBMAOABCHEADRA2BADRA2C | |
| SCHEMBL16192661 | 0.69 | HDAC9 (0.35) | MAOBMAOASIGMAR1HDAC9ALDH1A1 | |
| SCHEMBL27967814 | 0.69 | KDM1A (0.39) | MAOBMAOAKDM1ASIGMAR1ALDH1A1 | |
| SCHEMBL14860973 | 0.69 | KDM1A (0.38) | MAOBMAOABCHEADRA2BADRA2C | |
| SCHEMBL14840033 | 0.66 | HDAC9 (0.34) | MAOBMAOAKDM1ASIGMAR1HDAC9 | |
| SCHEMBL29453777 | 0.66 | KDM1A (0.42) | MAOBKDM1ASIGMAR1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1038928-C | Mono-fluorinated derivatives of N-propargyl-1-aminoindan and their use as inhibitors of monoamine oxidase | TEVA PHARMA (NL) | 1998-07-01 | — | — | CN | claimed |
| EP-0538134-B1 | Mono-fluorinated derivatives of N-propargyl-1-aminoindan and their use as inhibitors of monoamine oxidase | TEVA PHARMA (IL) | 1997-03-12 | — | — | EP | claimed |
| CN-1073427-A | Phenyl ring list fluorizated N-propargyl-1-aminoidan reaches the selective depressant as monoamine oxidase (MAO) | TEVA PHARMA (IL) | 1993-06-23 | — | — | CN | claimed |
| EP-0538134-A2 | Mono-fluorinated derivatives of N-propargyl-1-aminoindan and their use as inhibitors of monoamine oxidase | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1993-04-21 | — | — | EP | claimed |
| CN-1038928-C | Mono-fluorinated derivatives of N-propargyl-1-aminoindan and their use as inhibitors of monoamine oxidase | TEVA PHARMA (NL) | 1998-07-01 | — | — | CN | disclosed |
| EP-0538134-B1 | Mono-fluorinated derivatives of N-propargyl-1-aminoindan and their use as inhibitors of monoamine oxidase | TEVA PHARMA (IL) | 1997-03-12 | — | — | EP | disclosed |
| US-5486541-A | FOR TREATING PARKINSON*S DISEASE, MEMORY DISORDERS, ALZHEIMER*S DISEASE, DEPRESSION OR HYPERACTIVE SYNDROME | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1996-01-23 | — | — | US | disclosed |
| CN-1073427-A | Phenyl ring list fluorizated N-propargyl-1-aminoidan reaches the selective depressant as monoamine oxidase (MAO) | TEVA PHARMA (IL) | 1993-06-23 | — | — | CN | disclosed |
| EP-0538134-A2 | Mono-fluorinated derivatives of N-propargyl-1-aminoindan and their use as inhibitors of monoamine oxidase | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1993-04-21 | — | — | EP | disclosed |