Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | GALR2 | O43603 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | CCR6 | P51684 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968033 | 0.89 | ALDH1A1 (0.51) | TSHRALDH1A1LMNAMAPTAKR1B1 | |
| SCHEMBL3726022 | 0.82 | TSHR (0.49) | TSHRALDH1A1SMN1; SMN2LMNAPOLB | |
| SCHEMBL2298369 | 0.80 | TDP1 (0.45) | ALDH1A1SMN1; SMN2GALR2MITFLMNA | |
| SCHEMBL17665562 | 0.79 | GRM8 (0.47) | TSHRALDH1A1SMN1; SMN2LMNAMAPT | |
| SCHEMBL7649624 | 0.79 | SIRT6 (0.47) | ALDH1A1SMN1; SMN2GALR2MITFLMNA | |
| SCHEMBL11302461 | 0.78 | ALDH1A1 (0.50) | ALDH1A1LMNAMAPTL3MBTL1TDP1 | |
| SCHEMBL30875689 | 0.78 | ALDH1A1 (0.50) | ALDH1A1LMNAMAPTL3MBTL1TDP1 | |
| SCHEMBL1455839 | 0.78 | MEN1 (0.50) | TSHRRXRAALDH1A1LMNANPSR1 | |
| SCHEMBL2597715 | 0.78 | KMT2A (0.41) | ALDH1A1SMN1; SMN2GALR2MITFLMNA | |
| SCHEMBL7941824 | 0.78 | KMT2A (0.62) | TSHRALDH1A1SMN1; SMN2GALR2MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6284796-B1 | NAPHTHAMIDINE COMPOUNDS | ABBOTT LABORATORIES | 2001-09-04 | — | — | US | disclosed |