Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | PTAFR | P25105 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 4/20 | 0.32 |
| ▸ | RAB9A | P51151 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | JUN | P05412 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7343297 | 1.00 | PTGS1 (0.35) | PTGS1PTGS2ALOX5CYP11B1CYP11B2 | |
| SCHEMBL7342205 | 1.00 | PTGS1 (0.35) | PTGS1PTGS2ALOX5CYP11B1CYP11B2 | |
| SCHEMBL7340227 | 0.77 | CYP11B1 (0.42) | PTGS1PTGS2ALOX5CYP11B1CYP11B2 | |
| SCHEMBL7340223 | 0.77 | CYP11B1 (0.42) | PTGS1PTGS2ALOX5CYP11B1CYP11B2 | |
| SCHEMBL7345200 | 0.77 | CYP11B1 (0.42) | PTGS1PTGS2ALOX5CYP11B1CYP11B2 | |
| SCHEMBL27802133 | 0.73 | CYP11B1 (0.57) | PTGS1PTGS2ALOX5CYP11B1CYP11B2 | |
| SCHEMBL7340708 | 0.72 | CHRNB2 (0.43) | PTGS2NPC1CHRNB2CHRNA4 | |
| SCHEMBL7340701 | 0.72 | CHRNB2 (0.43) | PTGS2NPC1CHRNB2CHRNA4 | |
| SCHEMBL7348148 | 0.72 | CHRNB2 (0.43) | PTGS2NPC1CHRNB2CHRNA4 | |
| SCHEMBL5949116 | 0.72 | NFE2L2 (0.40) | PTGS1PTGS2ALOX5NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0578080-B1 | 3,9-disubstituted-spiro (5.5)undecanes active on the cardiovascular system, process for their preparation and pharmaceutical composition containing same | SIGMA TAU IND FARMACEUTI (IT) | 1997-04-23 | — | — | EP | disclosed |
| US-5444082-A | Treats hypertension and heart failure | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1995-08-22 | — | — | US | disclosed |
| EP-0578080-A2 | 3,9-disubstituted-spiro (5.5)undecanes active on the cardiovascular system, process for their preparation and pharmaceutical composition containing same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1994-01-12 | — | — | EP | disclosed |