Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | CLK2 | P49760 | 1/20 | 0.39 |
| ▸ | CLK3 | P49761 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 3/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7340708 | 1.00 | CHRNB2 (0.43) | CHRNB2CHRNA4SIGMAR1CLK2CLK3 | |
| SCHEMBL7340701 | 1.00 | CHRNB2 (0.43) | CHRNB2CHRNA4SIGMAR1CLK2CLK3 | |
| SCHEMBL7341014 | 0.79 | LTA4H (0.38) | LTA4HPTGS2NPC1 | |
| SCHEMBL7337816 | 0.76 | LTA4H (0.46) | CHRNB2CHRNA4SIGMAR1LTA4HCHRM2 | |
| SCHEMBL7345200 | 0.74 | CYP11B1 (0.42) | PTGS2NPC1 | |
| SCHEMBL7340223 | 0.74 | CYP11B1 (0.42) | PTGS2NPC1 | |
| SCHEMBL7340227 | 0.74 | CYP11B1 (0.42) | PTGS2NPC1 | |
| SCHEMBL7343297 | 0.72 | PTGS1 (0.35) | CHRNB2CHRNA4PTGS2NPC1 | |
| SCHEMBL7342196 | 0.72 | PTGS1 (0.35) | CHRNB2CHRNA4PTGS2NPC1 | |
| SCHEMBL7342205 | 0.72 | PTGS1 (0.35) | CHRNB2CHRNA4PTGS2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0578080-B1 | 3,9-disubstituted-spiro (5.5)undecanes active on the cardiovascular system, process for their preparation and pharmaceutical composition containing same | SIGMA TAU IND FARMACEUTI (IT) | 1997-04-23 | — | — | EP | disclosed |
| US-5444082-A | Treats hypertension and heart failure | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 1995-08-22 | — | — | US | disclosed |
| EP-0578080-A2 | 3,9-disubstituted-spiro (5.5)undecanes active on the cardiovascular system, process for their preparation and pharmaceutical composition containing same | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 1994-01-12 | — | — | EP | disclosed |