Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ECE1 | P42892 | 4/20 | 0.54 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.52 |
| ▸ | CPA1 | P15085 | 3/20 | 0.51 |
| ▸ | MME | P08473 | 3/20 | 0.51 |
| ▸ | ACE | P12821 | 2/20 | 0.51 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.51 |
| ▸ | ANPEP | P15144 | 2/20 | 0.50 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.50 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.50 |
| ▸ | CPA2 | P48052 | 2/20 | 0.49 |
| ▸ | CPA4 | Q9UI42 | 2/20 | 0.49 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 3/20 | 0.46 |
| ▸ | MMP9 | P14780 | 2/20 | 0.46 |
| ▸ | MMP8 | P22894 | 2/20 | 0.46 |
| ▸ | PYGB | P11216 | 1/20 | 0.45 |
| ▸ | CTSD | P07339 | 1/20 | 0.45 |
| ▸ | MMP3 | P08254 | 2/20 | 0.45 |
| ▸ | MMP14 | P50281 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7307671 | 0.87 | ERAP2 (0.58) | ECE1MMEACEANPEPERAP2 | |
| SCHEMBL7306489 | 0.87 | ERAP2 (0.68) | ECE1MMEACEANPEPERAP2 | |
| SCHEMBL7312264 | 0.85 | ACE (0.58) | CPA1ACEERAP2ERAP1CPA2 | |
| SCHEMBL7312238 | 0.85 | ACE (0.58) | CPA1ACEERAP2ERAP1CPA2 | |
| SCHEMBL7315009 | 0.82 | ERAP2 (0.64) | ECE1MMEACEANPEPERAP2 | |
| SCHEMBL7307608 | 0.82 | ERAP2 (0.62) | ECE1ACEANPEPERAP2ERAP1 | |
| SCHEMBL6412335 | 0.81 | MMP1 (0.56) | CPA1ERAP2ERAP1CPA2CPA4 | |
| SCHEMBL6412324 | 0.81 | MMP1 (0.56) | CPA1ERAP2ERAP1CPA2CPA4 | |
| SCHEMBL7304171 | 0.81 | ECE1 (0.63) | ECE1MMEACEANPEPERAP2 | |
| SCHEMBL7306818 | 0.80 | ERAP1 (0.59) | ECE1MMEACEANPEPERAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5380921-A | Enzyme inhibitors for endothelin converting enzyme for cardiovascular disorders and atherosclerosis | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1995-01-10 | — | — | US | disclosed |
| EP-0623625-A1 | Aminophosphonic acid derivative | BANYU PHARMACEUTICAL CO., LTD. (JP) | 1994-11-09 | — | — | EP | disclosed |