Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | EDNRA | P25101 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338551 | 0.92 | ALDH1A1 (0.39) | HSD11B1EDNRAHPGDHCRTR2ALDH1A1 | |
| SCHEMBL7339606 | 0.90 | EDNRA (0.38) | HSD11B1EDNRAHCRTR2ALDH1A1KDM4E | |
| SCHEMBL7341811 | 0.90 | EDNRA (0.38) | HSD11B1EDNRAHCRTR2ALDH1A1KDM4E | |
| SCHEMBL7336270 | 0.89 | HCRTR2 (0.41) | HSD11B1EDNRAHPGDHCRTR2ALDH1A1 | |
| SCHEMBL7822983 | 0.86 | EDNRA (0.41) | HSD11B1EDNRAHPGDHCRTR2ALDH1A1 | |
| SCHEMBL7337701 | 0.86 | EDNRA (0.41) | EDNRASMN1; SMN2NPC1KMT2AMEN1 | |
| SCHEMBL7338776 | 0.86 | EDNRA (0.41) | EDNRASMN1; SMN2NPC1KMT2AMEN1 | |
| SCHEMBL7334097 | 0.84 | HSD11B1 (0.49) | HSD11B1EDNRAHPGDHCRTR2ALDH1A1 | |
| SCHEMBL6542054 | 0.82 | HSD11B1 (0.52) | HSD11B1EDNRAHPGDALDH1A1TP53 | |
| SCHEMBL7336961 | 0.82 | HPGD (0.47) | HSD11B1EDNRAHPGDHCRTR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | claimed |
| WO-1996026195-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-08-29 | — | — | WO | claimed |
| EP-0811001-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1997-12-10 | — | — | EP | disclosed |
| WO-1996026195-A1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1996-08-29 | — | — | WO | disclosed |