Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7831316 | 0.90 | EDNRA (0.37) | EDNRAHCRTR2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7817685 | 0.90 | EDNRA (0.37) | EDNRAHCRTR2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL7828399 | 0.89 | HCRTR2 (0.41) | EDNRAHCRTR2ALDH1A1L3MBTL1HPGD | |
| SCHEMBL7343148 | 0.86 | HSD11B1 (0.44) | EDNRAHCRTR2HSD11B1ALDH1A1L3MBTL1 | |
| SCHEMBL7828475 | 0.86 | EDNRA (0.40) | EDNRAMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL7824156 | 0.84 | ALDH1A1 (0.46) | EDNRAHCRTR2HSD11B1ALDH1A1L3MBTL1 | |
| SCHEMBL7827530 | 0.80 | HSD11B1 (0.43) | EDNRAHSD11B1ALDH1A1L3MBTL1HTT | |
| SCHEMBL7832196 | 0.79 | HSD11B1 (0.43) | HSD11B1ALDH1A1L3MBTL1LMNAHTT | |
| SCHEMBL7831589 | 0.79 | HSD11B1 (0.49) | HSD11B1SMN1; SMN2HTTCYP1A2CYP2C19 | |
| SCHEMBL7338551 | 0.78 | ALDH1A1 (0.39) | EDNRAHCRTR2HSD11B1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0811001-B1 | BENZOTHIAZINE DIOXIDES AS ENDOTHELIN ANTAGONISTS | WARNER LAMBERT CO (US) | 2001-10-31 | — | — | EP | claimed |