Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 16/20 | 0.46 |
| ▸ | ITGAV | P06756 | 16/20 | 0.46 |
| ▸ | ITGB6 | P18564 | 11/20 | 0.46 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.46 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.46 |
| ▸ | ITGB5 | P18084 | 2/20 | 0.46 |
| ▸ | ITGB8 | P26012 | 2/20 | 0.46 |
| ▸ | ITGA8 | P53708 | 2/20 | 0.46 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7836365 | 0.93 | ITGB3 (0.52) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL6778108 | 0.88 | ITGB3 (0.54) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL7341087 | 0.86 | GPR139 (0.48) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL7835622 | 0.85 | ITGB3 (0.42) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL7339148 | 0.85 | F7 (0.44) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL7340506 | 0.85 | ITGB3 (0.49) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL7836347 | 0.84 | NPC1 (0.45) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL3839471 | 0.84 | GPR139 (0.47) | ITGB3ITGAVITGB1ITGA5GPR139 | |
| SCHEMBL7341726 | 0.83 | GPR139 (0.42) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL7823060 | 0.83 | ITGB3 (0.38) | ITGB3ITGAVITGB6ITGB1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |