Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 3/20 | 0.49 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.49 |
| ▸ | ITGAV | P06756 | 3/20 | 0.49 |
| ▸ | ITGA5 | P08648 | 3/20 | 0.49 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.49 |
| ▸ | ITGB6 | P18564 | 3/20 | 0.49 |
| ▸ | ITGB8 | P26012 | 3/20 | 0.49 |
| ▸ | ITGA8 | P53708 | 3/20 | 0.49 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6778768 | 0.89 | ITGB3 (0.60) | ITGB3ITGB1ITGAVITGA5ITGB5 | |
| SCHEMBL7341726 | 0.88 | GPR139 (0.42) | ITGB3ITGB1ITGAVITGA5ITGB5 | |
| SCHEMBL3839471 | 0.87 | GPR139 (0.47) | ITGB3ITGB1ITGAVITGA5GPR139 | |
| SCHEMBL7339495 | 0.85 | KMT2A (0.44) | ITGB3ITGB1ITGAVITGA5ITGB5 | |
| SCHEMBL7344103 | 0.85 | ITGB3 (0.46) | ITGB3ITGB1ITGAVITGA5ITGB5 | |
| SCHEMBL7834703 | 0.85 | ITGB3 (0.48) | ITGB3ITGB1ITGAVITGA5ITGB5 | |
| SCHEMBL7340341 | 0.84 | F7 (0.41) | ITGB3ITGB1ITGAVITGA5ITGB5 | |
| SCHEMBL7337752 | 0.84 | NPC1 (0.44) | ITGB3ITGB1ITGAVITGA5ITGB5 | |
| SCHEMBL7836067 | 0.84 | ITGB3 (0.52) | ITGB3ITGB1ITGAVITGA5ITGB5 | |
| SCHEMBL7823382 | 0.84 | MAPT (0.41) | ITGB3ITGB1ITGAVITGA5ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | disclosed |
| US-6028223-A | AN INTEGRIN ANTAGONISTS TREATING BONE DISORDER, PERIODONTAL DISEASE, OSTEOPOROSIS, HUMORAL HYPERCALCEMIA OF MALIGNANCY, PAGET'S DISEASE, TUMOR ANGIOGENESIS, DIABETIC RETINOPATHY, ARTHRITIS, SMOOTH MUSCLE CELL MIGRATION AND RESTENOSIS | G. D. SEARLE & CO. (US) | 2000-02-22 | — | — | US | disclosed |
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | disclosed |