Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | APEX1 | P27695 | 1/20 | 0.53 |
| ▸ | STIM1 | Q13586 | 2/20 | 0.43 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.43 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.43 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PREP | P48147 | 1/20 | 0.41 |
| ▸ | FAP | Q12884 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.41 |
| ▸ | FEN1 | P39748 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30064136 | 0.81 | SIRT3 (0.43) | POLBAPEX1SMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL1423953 | 0.81 | SIRT3 (0.43) | POLBAPEX1SMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL1423962 | 0.79 | RAB9A (0.42) | POLBAPEX1SMN1; SMN2HPGDKDM4C | |
| SCHEMBL28828166 | 0.78 | SIRT3 (0.56) | POLBAPEX1SMN1; SMN2HPGDL3MBTL1 | |
| SCHEMBL28064901 | 0.78 | POLB (0.57) | POLBAPEX1SMN1; SMN2HPGDSYK | |
| SCHEMBL2998183 | 0.77 | KDM4E (0.50) | STIM1ORAI1TRPC1TRPC3SMN1; SMN2 | |
| SCHEMBL24568249 | 0.77 | PREP (0.55) | STIM1ORAI1TRPC1TRPC3PREP | |
| SCHEMBL30171323 | 0.77 | HPGD (0.42) | POLBAPEX1SMN1; SMN2HPGDSYK | |
| SCHEMBL28948291 | 0.77 | HPGD (0.42) | POLBAPEX1SMN1; SMN2HPGDSYK | |
| SCHEMBL17180153 | 0.77 | TP53 (0.54) | POLBSTIM1ORAI1TRPC1TRPC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997036902-A1 | TRANS-2,6-, 3,6- AND 4,6-DIAZA-5,6,6a,7,8,12b-HEXAHYDROBENZO[C]PHENANTHRENE COMPOUNDS AS DOPAMINE AGONISTS | ABBOTT LABORATORIES (US) | 1997-10-09 | — | — | WO | disclosed |
| US-5668141-A | TREATMENT OF PSYCHOLOGICAL, NEUROLOGICAL AND CARDIOVASCULAR DISORDERS | ABBOTT LABORATORIES (US) | 1997-09-16 | — | — | US | disclosed |