Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.41 |
| ▸ | SYK | P43405 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1423953 | 1.00 | SIRT3 (0.43) | SIRT3TDP1POLBSMN1; SMN2HPGD | |
| SCHEMBL28828166 | 0.86 | SIRT3 (0.56) | SIRT3TDP1POLBSMN1; SMN2HPGD | |
| SCHEMBL7344134 | 0.81 | POLB (0.53) | POLBSMN1; SMN2HPGDAPEX1KDM4C | |
| SCHEMBL30674829 | 0.80 | KDM4C (0.49) | SIRT3TDP1SMN1; SMN2HPGDTYK2 | |
| SCHEMBL1423962 | 0.80 | RAB9A (0.42) | POLBSMN1; SMN2HPGDAPEX1KDM4C | |
| SCHEMBL2989594 | 0.79 | KDM4E (0.50) | SIRT3TDP1TYK2KDM4CL3MBTL1 | |
| SCHEMBL28948291 | 0.78 | HPGD (0.42) | SIRT3TDP1POLBSMN1; SMN2HPGD | |
| SCHEMBL30171323 | 0.78 | HPGD (0.42) | SIRT3TDP1POLBSMN1; SMN2HPGD | |
| SCHEMBL24997725 | 0.76 | KDM5A (0.45) | SIRT3TDP1TYK2KDM4CL3MBTL1 | |
| SCHEMBL29467545 | 0.76 | ALDH1A1 (0.51) | SIRT3TDP1HPGDTYK2KDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4347594-A1 | 2, 8-DIAZASPIRO [4.5] DECANE COMPOUNDS | Genentech, Inc. (US) | 2024-04-10 | — | — | EP | disclosed |
| WO-2022253341-A1 | 2, 8-DIAZASPIRO [4.5] DECANE COMPOUNDS | GENENTECH, INC. (US) | 2022-12-08 | — | — | WO | disclosed |