Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.69 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.69 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.69 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.69 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.69 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.69 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.69 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.69 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.69 |
| ▸ | PRCP | P42785 | 1/20 | 0.69 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.69 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.69 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.69 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.67 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.67 |
| ▸ | NPY1R | P25929 | 1/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.45 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7344204 | 1.00 | SIGMAR1 (0.69) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL1764442 | 0.87 | SIGMAR1 (0.69) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| Hydrochloric Acid SCHEMBL28605245 | 0.85 | OPRM1 (0.70) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL28282384 | 0.84 | GRIN1 (0.88) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL4049565 | 0.83 | SIGMAR1 (0.69) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL1262555 | 0.83 | SIGMAR1 (0.69) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL8357591 | 0.83 | NPY1R (0.68) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| SCHEMBL9153279 | 0.82 | SIGMAR1 (1.00) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| Rolicyclidine SCHEMBL517928 | 0.82 | SIGMAR1 (1.00) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D | |
| Phencyclidine SCHEMBL42022 | 0.82 | SIGMAR1 (1.00) | SIGMAR1GRIN1GRIN2AGRIN2BGRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6114381-A | TO CONTROL BRAIN DAMAGE ASSOCIATED WITH ANOXIA OR ISCHEMIA WHICH TYPICALLY FOLLOWS STROKE, CARDIAC ARREST OR PERINATAL ASPHYXIA; COMPOUND IS AN ANTAGONIST TO INHIBIT EXCITOTOXIC ACTIONS AT EXCITATORY AMINO ACID RECEPTOR SITES | G. D. SEARLE & CO. (US) | 2000-09-05 | — | — | US | disclosed |
| US-5604255-A | N-(1-thienylcycloalkyl)alkenylamines for treatment of neurotoxic injury | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1997-02-18 | — | — | US | disclosed |
| US-5401755-A | Related to ischemic, hypoxic or anoxic conditions, reducing brain damage | G. D. SEARLE & CO. (US) | 1995-03-28 | — | — | US | disclosed |
| EP-0346791-B1 | 1,2-diarylethylamines for treatment of neurotoxic injury | SEARLE & CO (US) | 1994-04-06 | — | — | EP | disclosed |
| US-4945097-A | THERAPY FOR ANOXIA, HYPOXIA, OR ISCHEMIA | G. D. SEARLE & CO. (US) | 1990-07-31 | — | — | US | disclosed |
| EP-0346791-A1 | 1,2-diarylethylamines for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1989-12-20 | — | — | EP | disclosed |
| US-4837218-A | CONTROLLING BRAIN DAMAGE FROM ANOXIA OR ISCHEMIA | WASHINGTON UNIVERSITY (US) | 1989-06-06 | — | — | US | disclosed |
| EP-0317953-A2 | N-(1-thienylcycloalkyl)alkenylamines for treatment of neurotoxic injury | G.D. Searle & Co. (US) | 1989-05-31 | — | — | EP | disclosed |
| US-4833138-A | Phenothiazinealkaneamines for treatment of neurotoxic injury | WASHINGTON UNIVERSITY (US) | 1989-05-23 | — | — | US | disclosed |